Early Detection

A comprehensive approach to ‘early detection’ must include individual risk, prevention, screening, improved symptomatic diagnosis, and management of early disease. There are several research programmes in this domain in Cambridge, and as yet untapped expertise in many applicable technologies. Additional funding as one of the CRUK Major Centres provides an opportunity to develop early detection as a major focus of the Cambridge Cancer Centre with an integrated approach across basic research in the physical and biological sciences, population science and clinical research.

Addressing fundamental questions in early detection of cancer

Programme Contacts

University of Cambridge
MRC Cancer Unit
University of Cambridge
Department of Physics, Cancer Research UK Cambridge Institute
Cambridge Cancer Centre Early Detection Programme

Why early detection?  When cancer is found earlier, it can be easier to treat successfully.

 

What is the CCC “Early Detection” programme?  Early detection refers to the detection of cancer at an earlier time point in the natural history of the disease than would otherwise have occurred under current detection and diagnostic paradigms. While earlier detection might be considered in the context of detecting disease relapse, the Early Detection programme of the Cambridge Cancer Centre is limited to the detection of primary disease.

 CCC Early Detection Programme Aims

  • To create a strong, virtual network of groups in Cambridge with a focus on earlier detection.
  • To develop relevant population­ based and clinical resources.
  • To facilitate the creation of new programmes and projects focused on the detection of pre­invasive disease.
  • In the longer term to establish a physical “Early Detection Research Centre” to create a nucleus of activity within the Cambridge Cancer centre.

The Early Detection programme is truly multidisciplinary. Research within the Early Detection Programme encompasses:

  1. Biology of cancer initiation and progression to invasion in order to: better understand the natural history of disease; identify biomarkers relating to individual disease risk, detection and prediction
  2. The development and evaluation of new methods of detecting invasive and pre­invasive lesions.
  3. Clinical studies to evaluate new preventative and therapeutic interventions arising from 1) and 2), with regard to improving clinical outcomes.

Projects in the Early Detection programme include:

  • Investigation into the accumulation of amyloid as a biomarker for cancer
  • Using new technology to develop a test for oesophageal cancer
  • Development of a novel test for the diagnosis of prostate cancer
  • Investigation into the development of second primary tumours in survivors of previous upper aero­digestive cancers.

Principal investigators and consultants

  • All members
  • Group leaders
  • Clinical consultants
University of Cambridge
MRC Cancer Unit
Hutchison MRC Research Centre
My recent research focuses on the study of epithelial stem and progenitor cells. Particularly, I am interested on how the normal rules...
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(tbc)
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University of Cambridge
Department of Chemistry
We are interested in the chemical biology of nucleic acids and the genome. Our research explores the sequence, structure and function of...
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Functional Genomics of Breast Cancer. Development and utilisation of Patient derived tumour models in therapeutic research.
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Wellcome Trust MRC Cambridge Stem Cell Institute
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University of Cambridge
Wellcome Trust CRUK Gurdon Institute
In adult epidermis, Myc activation stimulates exit from the stem cell compartment by downregulating genes involved in cell adhesion and...
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University of Cambridge
Department of Physics, Cancer Research UK Cambridge Institute
Our passion is integrating new technological innovations into biomedical imaging that can help to improve our understanding of metabolic (...
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University of Cambridge
CRUK Cambridge Institute
Primary research focuses on understanding how the ageing process, and processes underlying ageing, promote carcinogenesis.
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University of Cambridge
Department of Pathology
Hutchison MRC Research Centre
Our group aims to translate basic scientific advances into improvements in the clinical management of neoplastic disease. We work in two...
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Cambridge University Hospitals NHS Foundation Trust, University of Cambridge
School of Clinical Medicine, Department of Surgery, MRC Cancer Unit
Hutchison MRC Research Centre, CRUK Cambridge Institute
I am interested in cancer genomics and the role of structural variants in progression and maintenance of oesophageal adenocarcinoma.
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(tbc)
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University of Cambridge
Department of Public Health and Primary Care
Centre for Cancer Genetic Epidemiology
I am a bioinformatician who has worked on the design, variant annotation, data handling, quality control, imputation and analysis of large...
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University of Cambridge
MRC Cancer Unit
Hutchison MRC Research Centre
I have an interest in early detection of upper gastro-intestinal cancer, with particular attention to oesophageal cancer and risk...
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University of Cambridge
Cancer Research UK Cambridge Institute
CRUK Cambridge Institute
I have been working on the analysis of microarray and High-throughput sequencing data for several years. Most of my work is done using open...
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University of Cambridge
Department of Oncology
Strangeways Research Laboratory
Work in the Centre for Cancer Genetic Epidemiology "wet lab" involves running very high throughput SNP-chip genotyping and Next Generation...
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(tbc)
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University of Cambridge
MRC Cancer Unit
Hutchison MRC Research Centre
Oesophageal cancer is a global health problem. The work of my laboratory and clinical team is driven by a clinical need to identify...
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Department of Engineering
I am developing a capsule endoscope to aid in the early detection of oesophageal cancer.
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University of Cambridge
MRC Cancer Unit
Hutchison MRC Research Centre
By using a combination of biochemistry, metabolomics, and systems biology we investigate the role of altered metabolism in cancer with the...
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Development of circulating tumour DNA (ctDNA) as a non-invasive liquid biopsy to improve personalised healthcare in oncology for patient...
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European Bioinformatics Institute
Computational Cancer Biology Clinical decision support Evolution Mutational processes
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Wellcome Trust Sanger Institute
Development of computational and experimental methods of sampling menstrual effluent for the early diagnosis and study of epithelial...
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University of Cambridge
Department of Gastroenterology
An optical communications engineer by background, I am now developing new types of optical fibre endoscopes that measure additional...
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Oesophageal cancer Barrett's Oesophagus General Cancer Cell Biology
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Cambridge University Hospitals NHS Foundation Trust
Department of Pathology
(tbc)
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Cambridge University Hospitals NHS Foundation Trust
Upper Gastrointestinal (GI) Unit
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University of Cambridge
Department of Engineering
My research group is interested in designing and developing biomimetic organ-on-chips for high-throughput drug testing. Living tissues are...
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University of Cambridge
Department of Public Health and Primary Care
In adult mammals, self-renewal is required for the maintenance of tissue homeostasis and tissue repair. In organs with extensive self-...
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Cambridge University Hospitals NHS Foundation Trust
Breast Unit
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Y
My research focuses on ethical and epistemological issues arising in public health programmes. I have a specific interest in cancer...
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Wellcome Trust Sanger Institute, University of Cambridge
MRC Cancer Unit
Hutchison MRC Research Centre
Hon Consultant in Medical Oncology
Our group studies how normal cell behaviour is altered by mutation in the early stages of cancer evolution. We focus on squamous tissues,...
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University of Cambridge
Department of Chemistry
Using microscopic techniques such as Fluorescent Resonance Energy Transfer (FRET), Fluorescence Lifetime Imaging Microscopy (FLIM) and...
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Early detection in oesophageal adenocarcinoma
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MRC Biostatics Unit
I have interests in Bayesian methods for unsupervised genomic dataset integration, and many broad aspects of statistical and mathematical...
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University of Cambridge
Department of Clinical Genetics
We are interested in developing and applying a range of new biophysical methods, based on laser fluorescence spectroscopy and scanning...
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Various projects for Lung Cancer research. Main project working on is Mesobank, preforming the quality control for solid tissue collected.
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University of Cambridge
Department of Chemistry
We work on the physico-chemical properties and behaviour of biological molecules and soft materials. The research in the group is highly...
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AstraZeneca
As part of the Personalised Healthcare and Biomarker department of AstraZeneca, my role is to align the development of companion...
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University of Cambridge
Department of Biochemistry
The research carried out in the Cambridge Centre for Proteomics centres around three main areas: ? Development of quantitative proteomics...
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Cancer Epidemiology of ealry diagnosis
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The 'psycho-social' realities of early detection.
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Project title: Epithelial cell dynamics during postnatal growth; relevance for oesophageal cancer development Lead Supervisor: Dr Maria...
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University of Cambridge
Cancer Research UK Cambridge Institute
Genetic Susceptibility to Breast Cancer 1. Functional analysis of predisposition loci: My experiments are aimed at understanding the...
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University of Cambridge
Department of Public Health and Primary Care
Institute of Public Health
In the Primary Care Unit I've managed and collaborated on a number of randomised controlled trials and other well-designed studies in the...
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University of Cambridge
MRC Cancer Unit, Department of Oncology
Hutchison MRC Research Centre
(tbc)
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University of Cambridge
Department of Oncology
Hutchison MRC Research Centre
My group works at the interface between cellular senescence, plasticity and the fundamental processes and mechanisms that lie at the origin...
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University of Cambridge, Cancer Research UK Cancer Research Technologies (CRT)
Department of Oncology
As a chemical engineer, I enjoy translating basic science into novel biomedical technologies. I am interested in developing molecular...
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I investigate the structure and function of the normal and Barrett's oesophagus on the cellular level using single cell sequencing...
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University of Cambridge
Cancer Research UK Cambridge Institute
Hutchison MRC Research Centre
Application of computational biology approaches to integrate different types of 'omics'-data with a focus on improving our understanding of...
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University of Cambridge
Cancer Research UK Cambridge Institute
CRUK Cambridge Institute
Locus-by-locus analysis of GWAS loci to identify the causative snp(s) and their related genes has yielded useful insights.  However, this...
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University of Cambridge
Department of Engineering
Development of ultrafast fiber laser systems for medical applications, including surgery and imaging, such as coherent Raman microscopy.
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Babraham Institute
Epigenetics Programme
Our lab works on epigenetic mechanisms of gene regulation in mammalian development. We particularly focus on understanding the mechanisms...
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University of Cambridge
Cancer Research UK Cambridge Institute
We aim to develop novel diagnostic tools for cancer, through the application of molecular and genomic technologies. Our focus is on...
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University of Cambridge
MRC Cancer Unit
Hutchison MRC Research Centre
My lab develops multi-disciplinary data science, data engineering and computational biology solutions to understand multi-scale biological...
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University of Cambridge
Department of Veterinary Medicine
My lab is using genomic mapping techniques to identify genes associated with breed specific predispositions to particular cancers in dogs....
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University of Cambridge
Department of Engineering
Nanoscience Centre
One of the research thrusts in my group is the development of microelectromechanical and microfluidics based platforms for early diagnosis...
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University of Cambridge
Department of Pure Mathematics and Mathematical Statistics
(tbc)
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Cambridge University Hospitals NHS Foundation Trust
Department of Medical Genetics
Honorary Consultant in Medical Genetics
Marc Tischkowitz is a University Reader and Honorary Consultant in the Department of Medical Genetics at Cambridge. He completed his...
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University of Cambridge
Department of Engineering
Movel image analysis and imaging techniques involving CT, MRI and ultrasound. Particularly high resolution imaging of bone from clinical...
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University of Cambridge
Department of Public Health and Primary Care
My research focuses on the use of risk prediction models to promote behaviour change to help prevent cancer and inform stratified screening...
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University of Cambridge
Department of Clinical Neuroscience, Department of Engineering
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University of Cambridge
Department of Public Health and Primary Care
Institute of Public Health
Fiona’s portfolio of research is based in primary care, and focuses on the cancer continuum, including prevention, screening, early...
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(tbc)
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University of Cambridge
Cancer Research UK Cambridge Institute
Evolving NIR endoscopy for detection of dysplasia in patients with Barrett's oesophagus.
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University of Cambridge
Department of Radiology
Decision analytics, economic evaluation, efficient research design.
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