Professor Paul Pharoah

University position: Professor
Personal home page: http://www.phpc.cam.ac.uk/people/centre-for-cancer-genetic-epidemiology-people/ccge-senior-academic-staff/dr-paul-pharoah/

PubMed journal articles - click here

Professor Paul Pharoah is pleased to consider applications from prospective PhD students.

Research description

I am interested in the architecture of genetic susceptibility to common cancers (primarily breast, ovarian and colorectal). I am also interested in understanding how germline genetic variation influences disease heterogeneity and heterogeneity in the clinical outcomes of cancer.

Research Theme
Early detection and intervention
Personalised cancer medicine
Research Programme
Genetic epidemiology and cancer risk
Population sciences and primary care
Research Cancer Type
Breast cancer
Ovarian cancer
Prostate cancer
Methods and technologies
Public health
Statistical analysis
Tumour type interests
Ovary

Key publications

1.    PD Pharoah, YY Tsai, SJ Ramus, CM Phelan, EL Goode, K Lawrenson, M Buckley, BL Fridley, JP Tyrer, H Shen, R Weber, R Karevan, MC Larson, H Song, DC Tessier, F Bacot, D Vincent, JM Cunningham, J Dennis, E Dicks, KK Aben, H Anton-Culver, N Antonenkova, SM Armasu, L Baglietto, EV Bandera, MW Beckmann, MJ Birrer, G Bloom, N Bogdanova, JD Brenton, LA Brinton, A Brooks-Wilson, R Brown, R Butzow, I Campbell, ME Carney, RS Carvalho, J Chang-Claude, YA Chen, Z Chen, WH Chow, MS Cicek, G Coetzee, LS Cook, DW Cramer, C Cybulski, A Dansonka-Mieszkowska, E Despierre, JA Doherty, T Dork, A du Bois, M Durst, D Eccles, R Edwards, AB Ekici, PA Fasching, D Fenstermacher, J Flanagan, YT Gao, M Garcia-Closas, A Gentry-Maharaj, G Giles, A Gjyshi, M Gore, J Gronwald, Q Guo, MK Halle, P Harter, A Hein, F Heitz, P Hillemanns, M Hoatlin, E Hogdall, CK Hogdall, S Hosono, A Jakubowska, A Jensen, KR Kalli, BY Karlan, LE Kelemen, LA Kiemeney, SK Kjaer, GE Konecny, C Krakstad, J Kupryjanczyk, D Lambrechts, S Lambrechts, ND Le, N Lee, J Lee, A Leminen, BK Lim, J Lissowska, J Lubinski, L Lundvall, G Lurie, LF Massuger, K Matsuo, V McGuire, JR McLaughlin, U Menon, F Modugno, KB Moysich, T Nakanishi, SA Narod, RB Ness, H Nevanlinna, S Nickels, H Noushmehr, K Odunsi, S Olson, I Orlow, J Paul, T Pejovic, LM Pelttari, J Permuth-Wey, MC Pike, EM Poole, X Qu, HA Risch, L Rodriguez-Rodriguez, MA Rossing, A Rudolph, I Runnebaum, IK Rzepecka, HB Salvesen, I Schwaab, G Severi, H Shen, V Shridhar, XO Shu, W Sieh, MC Southey, P Spellman, K Tajima, SH Teo, KL Terry, PJ Thompson, A Timorek, SS Tworoger, AM van Altena, D van den Berg, I Vergote, RA Vierkant, AF Vitonis, S Wang-Gohrke, N Wentzensen, AS Whittemore, E Wik, B Winterhoff, YL Woo, AH Wu, HP Yang, W Zheng, A Ziogas, F Zulkifli, MT Goodman, P Hall, DF Easton, CL Pearce, A Berchuck, G Chenevix-Trench, E Iversen, AN Monteiro, SA Gayther, JM Schildkraut, TA Sellers. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat. Genet. 2013;45(4):362-70.
2.    HR Ali, E Provenzano, SJ Dawson, FM Blows, B Liu, M Shah, HM Earl, CJ Poole, L Hiller, JA Dunn, SJ Bowden, C Twelves, JM Bartlett, SM Mahmoud, E Rakha, IO Ellis, S Liu, D Gao, TO Nielsen, PD Pharoah, C Caldas. Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients. Ann. Oncol. 2014;25(8):1536-43.
3.    FJ Candido Dos Reis, H Song, EL Goode, JM Cunningham, BL Fridley, MC Larson, K Alsop, E Dicks, P Harrington, SJ Ramus, A de Fazio, G Mitchell, S Fereday, KL Bolton, C Gourley, C Michie, BY Karlan, J Lester, C Walsh, I Cass, H Olsson, M Gore, J Benitez, MJ Garcia, IL Andrulis, AM Mulligan, G Glendon, I Blanco, C Lazaro, AS Whittemore, V McGuire, W Sieh, M Montagna, E Alducci, S Sadetzki, A Chetrit, A Kwong, SK Kjaer, A Jensen, E Hogdall, SL Neuhausen, RL Nussbaum, M Daly, MH Greene, PL Mai, JT Loud, KB Moysich, AE Toland, D Lambrechts, S Ellis, D Frost, JD Brenton, M Tischkowitz, DF Easton, AC Antoniou, G Chenevix-Trench, SA Gayther, DD Bowtell, PD Pharoah. Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer. Clin. Cancer Res. 2015;21(3):652-7.
4.    DF Easton, PD Pharoah, AC Antoniou, M Tischkowitz, SV Tavtigian, KL Nathanson, P Devilee, A Meindl, FJ Couch, M Southey, DE Goldgar, DG Evans, G Chenevix-Trench, N Rahman, M Robson, SM Domchek, WD Foulkes. Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk. N. Engl. J. Med. 2015.
5.    Q Guo, MK Schmidt, P Kraft, S Canisius, C Chen, S Khan, J Tyrer, MK Bolla, Q Wang, J Dennis, K Michailidou, M Lush, S Kar, J Beesley, AM Dunning, M Shah, K Czene, H Darabi, M Eriksson, D Lambrechts, C Weltens, K Leunen, SE Bojesen, BG Nordestgaard, SF Nielsen, H Flyger, J Chang-Claude, A Rudolph, P Seibold, D Flesch-Janys, C Blomqvist, K Aittomaki, R Fagerholm, TA Muranen, FJ Couch, JE Olson, C Vachon, IL Andrulis, JA Knight, G Glendon, AM Mulligan, A Broeks, FB Hogervorst, CA Haiman, BE Henderson, F Schumacher, L Le Marchand, JL Hopper, H Tsimiklis, C Apicella, MC Southey, A Cox, SS Cross, MW Reed, GG Giles, RL Milne, C McLean, R Winqvist, K Pylkas, A Jukkola-Vuorinen, M Grip, MJ Hooning, A Hollestelle, JW Martens, AM van den Ouweland, F Marme, A Schneeweiss, R Yang, B Burwinkel, J Figueroa, SJ Chanock, J Lissowska, EJ Sawyer, I Tomlinson, MJ Kerin, N Miller, H Brenner, AK Dieffenbach, V Arndt, B Holleczek, A Mannermaa, V Kataja, VM Kosma, JM Hartikainen, J Li, JS Brand, K Humphreys, P Devilee, RA Tollenaar, C Seynaeve, P Radice, P Peterlongo, B Bonanni, P Mariani, PA Fasching, MW Beckmann, A Hein, AB Ekici, G Chenevix-Trench, R Balleine, I kConFab, KA Phillips, J Benitez, MP Zamora, JI Arias Perez, P Menendez, A Jakubowska, J Lubinski, K Jaworska-Bieniek, K Durda, U Hamann, M Kabisch, HU Ulmer, T Rudiger, S Margolin, V Kristensen, S Nord, DG Evans, JE Abraham, HM Earl, L Hiller, JA Dunn, S Bowden, C Berg, D Campa, WR Diver, SM Gapstur, MM Gaudet, SE Hankinson, RN Hoover, A Husing, R Kaaks, MJ Machiela, W Willett, M Barrdahl, F Canzian, SF Chin, C Caldas, DJ Hunter, S Lindstrom, M Garcia-Closas, P Hall, DF Easton, DM Eccles, N Rahman, H Nevanlinna, PD Pharoah. Identification of novel genetic markers of breast cancer survival. J. Natl. Cancer Inst. 2015;107(5).
6.    KB Kuchenbaecker, SJ Ramus, J Tyrer, A Lee, HC Shen, J Beesley, K Lawrenson, L McGuffog, S Healey, JM Lee, TJ Spindler, YG Lin, T Pejovic, Y Bean, Q Li, S Coetzee, D Hazelett, A Miron, M Southey, MB Terry, DE Goldgar, SS Buys, R Janavicius, CM Dorfling, EJ van Rensburg, SL Neuhausen, YC Ding, TV Hansen, L Jonson, AM Gerdes, B Ejlertsen, D Barrowdale, J Dennis, J Benitez, A Osorio, MJ Garcia, I Komenaka, JN Weitzel, P Ganschow, P Peterlongo, L Bernard, A Viel, B Bonanni, B Peissel, S Manoukian, P Radice, L Papi, L Ottini, F Fostira, I Konstantopoulou, J Garber, D Frost, J Perkins, R Platte, S Ellis, Embrace, AK Godwin, RK Schmutzler, A Meindl, C Engel, C Sutter, OM Sinilnikova, GS Collaborators, F Damiola, S Mazoyer, D Stoppa-Lyonnet, K Claes, K De Leeneer, J Kirk, GC Rodriguez, M Piedmonte, DM O'Malley, M de la Hoya, T Caldes, K Aittomaki, H Nevanlinna, JM Collee, MA Rookus, JC Oosterwijk, R Breast Cancer Family, L Tihomirova, N Tung, U Hamann, C Isaccs, M Tischkowitz, EN Imyanitov, MA Caligo, IG Campbell, FB Hogervorst, Hebon, E Olah, O Diez, I Blanco, J Brunet, C Lazaro, MA Pujana, A Jakubowska, J Gronwald, J Lubinski, G Sukiennicki, RB Barkardottir, M Plante, J Simard, P Soucy, M Montagna, S Tognazzo, MR Teixeira, KC Investigators, VS Pankratz, X Wang, N Lindor, CI Szabo, N Kauff, J Vijai, CA Aghajanian, G Pfeiler, A Berger, CF Singer, MK Tea, CM Phelan, MH Greene, PL Mai, G Rennert, AM Mulligan, S Tchatchou, IL Andrulis, G Glendon, AE Toland, UB Jensen, TA Kruse, M Thomassen, A Bojesen, J Zidan, E Friedman, Y Laitman, M Soller, A Liljegren, B Arver, Z Einbeigi, M Stenmark-Askmalm, OI Olopade, RL Nussbaum, TR Rebbeck, KL Nathanson, SM Domchek, KH Lu, BY Karlan, C Walsh, J Lester, S Australian Cancer, G Australian Ovarian Cancer Study, A Hein, AB Ekici, MW Beckmann, PA Fasching, D Lambrechts, E Van Nieuwenhuysen, I Vergote, S Lambrechts, E Dicks, JA Doherty, KG Wicklund, MA Rossing, A Rudolph, J Chang-Claude, S Wang-Gohrke, U Eilber, KB Moysich, K Odunsi, L Sucheston, S Lele, LR Wilkens, MT Goodman, PJ Thompson, YB Shvetsov, IB Runnebaum, M Durst, P Hillemanns, T Dork, N Antonenkova, N Bogdanova, A Leminen, LM Pelttari, R Butzow, F Modugno, JL Kelley, RP Edwards, RB Ness, A du Bois, F Heitz, I Schwaab, P Harter, K Matsuo, S Hosono, S Orsulic, A Jensen, SK Kjaer, E Hogdall, HN Hasmad, MA Azmi, SH Teo, YL Woo, BL Fridley, EL Goode, JM Cunningham, RA Vierkant, F Bruinsma, GG Giles, D Liang, MA Hildebrandt, X Wu, DA Levine, M Bisogna, A Berchuck, ES Iversen, JM Schildkraut, P Concannon, RP Weber, DW Cramer, KL Terry, EM Poole, SS Tworoger, EV Bandera, I Orlow, SH Olson, C Krakstad, HB Salvesen, IL Tangen, L Bjorge, AM van Altena, KK Aben, LA Kiemeney, LF Massuger, M Kellar, A Brooks-Wilson, LE Kelemen, LS Cook, ND Le, C Cybulski, H Yang, J Lissowska, LA Brinton, N Wentzensen, C Hogdall, L Lundvall, L Nedergaard, H Baker, H Song, D Eccles, I McNeish, J Paul, K Carty, N Siddiqui, R Glasspool, AS Whittemore, JH Rothstein, V McGuire, W Sieh, BT Ji, W Zheng, XO Shu, YT Gao, B Rosen, HA Risch, JR McLaughlin, SA Narod, AN Monteiro, A Chen, HY Lin, J Permuth-Wey, TA Sellers, YY Tsai, Z Chen, A Ziogas, H Anton-Culver, A Gentry-Maharaj, U Menon, P Harrington, AW Lee, AH Wu, CL Pearce, G Coetzee, MC Pike, A Dansonka-Mieszkowska, A Timorek, IK Rzepecka, J Kupryjanczyk, M Freedman, H Noushmehr, DF Easton, K Offit, FJ Couch, S Gayther, PP Pharoah, AC Antoniou, G Chenevix-Trench, B Consortium of Investigators of Modifiers of, Brca. Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat. Genet. 2015;47(2):164-71.
7.    SJ Ramus, H Song, E Dicks, JP Tyrer, AN Rosenthal, MP Intermaggio, L Fraser, A Gentry-Maharaj, J Hayward, S Philpott, C Anderson, CK Edlund, D Conti, P Harrington, D Barrowdale, DD Bowtell, K Alsop, G Mitchell, AS Group, MS Cicek, JM Cunningham, BL Fridley, J Alsop, M Jimenez-Linan, S Poblete, S Lele, L Sucheston-Campbell, KB Moysich, W Sieh, V McGuire, J Lester, N Bogdanova, M Durst, P Hillemanns, C Ovarian Cancer Association, K Odunsi, AS Whittemore, BY Karlan, T Dork, EL Goode, U Menon, IJ Jacobs, AC Antoniou, PD Pharoah, SA Gayther. Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer. J. Natl. Cancer Inst. 2015;107(11).

Distribution of predicted “deleterious” mutations in the BRIP1 (A), BARD1 (B), NBN (C), and PALB2 (D) genes identified in germline of 3,300 ovarian cancer patients and 3,300 controls. The location of each mutation is shown with respect to domains of functional significance in the translated protein and the exon structure of the coding sequence. Mutations in cases are illustrated in black; mutations in controls are in green. Also shown is where a mutation was identified in more than individual (eg, x2, x3, etc)