Professor Rebecca Fitzgerald

University of Cambridge
MRC Cancer Unit
Hutchison MRC Research Centre

Position: Professor of Cancer Prevention
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PubMed journal articles - click here

Professor Rebecca Fitzgerald is pleased to consider applications from prospective PhD students.

Research description

Oesophageal cancer is a global health problem. The work of my laboratory and clinical team is driven by a clinical need to identify patients with pre-invasive disease (Barrett?s oesophagus and squamous cell dysplasia) at high risk for cancer of the oesophagus so that they can be prevented from developing incurable invasive disease. This approach can at the same time be used to spare individuals at low risk unnecessary interventions. In addition, we are interested in applying genome-wide methods to identifying molecular targets for prognosis and therapy in established cancer of the oesophagus. In collaboration with Prof. Carlos Caldas we are also interested in the genetics, molecular pathogenesis and clinical of management of familial gastric cancer and Hereditary Diffuse Gastric Cancer in particular.

Research Programme
Early Detection
Massively parallel sequencing
Endoscopic imaging
Endoscopic therapy

Key publications

Bird-Lieberman EL, Neves AA, Lao-Sirieix P ... and Fitzgerald RC, Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett?s esophagus, 2012, Nature Medicine, 2012, 15(2):315-321 di Pietro M, Lao-Sirieix P, Fitzgerald RC, Evidence for a functional role of epigenetically regulated mid-cluster HOXB genes in the development of Barrett's esophagus, PNAS, 2012, 109(23):9077-82 Paterson AL, Shannon NB, Lao-Sirieix P, ... and Fitzgerald RC, A systematic approach to therapeutic target selection in oesophago-gastric cancer, Gut, 2012, In press Bird-Lieberman EL, Dunn JM, Coleman HG, ...and Fitzgerald RC, Phase 3 population-based study reveals new risk-stratification biomarker panel for Barrett?s esophagus, Gastroenterology, 2012, In press Lao-Sirieix P and Fitzgerald RC, Screening for esophageal carcinoma, 2012, Nature Reviews Gastrointestinal Oncology, 2012, 9(5):278-287